Members

Centenary Institute of Cancer Medicine and Cell Biology (NSW)

Postal address:
Locked Bag No. 6, Newtown, NSW 2042
02 9565 6156
enquiries@centenary.org.au
www.centenary.org.au

Director: Professor Mathew Vadas
Chief Operating Officer: Dr Nick Pearce

Principal Affiliations
University of Sydney
Royal Prince Alfred Hospital

Principal Areas of Research
Cancer 
Cardiovascular disease
Infectious diseases 

Major Current Research
Resistance to new and promising anti-cancer drugs that are being applied to treating common, recalcitrant tumours, including melanoma and multiple myeloma.

Understanding molecular pathways that repair damage to DNA and genes and the role of these pathways in cancer.

Examination of immunoregulatory mechanisms in infectious diseases and cancer by directly looking inside tissues as to how cells interact with their environment.

Role of sphingosine kinase in cancer, in particular beast cancer, cardiovascular disease and diabetes,3D structural studies of membrane proteins involved in cellular respiration, cell signalling and transport using x-ray crystallography.

Identification of genes and microRNAs that control the molecular events in angiogenesis and the mechanism of action in cardiovascular disease and cancer.

Understanding the basic biology of heart muscle function and defining novel ways to treat cardiovascular disorders, including cardiomyopathies, heart rhythm disorders and coronary artery disease.

Understanding why latent Tuberculosis (TB) infection progresses to active disease, how to improve the control of TB in highly endemic regions which is particularly important for containing the spread of drug-resistant TB, and developing better vaccines.

Understanding the how T-cell responses are controlled in order to design new therapies to prevent and/or treat diseases caused by dysregulated immune responses (eg allergic, autoimmune and inflammatory diseases).

Improving gene delivery in order to prevent the emergence of disease.

Investigating the unique immune response of the liver in a bid to further improve liver transplantation and find new, more effective ways to clear chronic infections such as investigating the structure and function of a group of enzymes that have a unique role in causing liver injury and cancer.